Panel Discussion – Engineering Matters to Counter the Tumor Microenvironment (TME) for Better Persistence

Time: 2:00 pm
day: Day One


  • Modifications to achieve blockade of checkpoints (e.g., PD1 KO) or other ligand signalling (e.g., TGFbeta dominant negative)
  • ‘Armouring’ cells with membrane-bound or secreted cytokines
  • Modulation of TME itself to increase tumor ‘warmth’
  • Dual- and multi-targeting to prevent antigen escape
  • Increasing the safety of therapies by adding ‘switches’ to turn on/off expression of required matters