Panel Discussion – Engineering Matters to Counter the Tumor Microenvironment (TME) for Better Persistence
Time: 2:00 pm
day: Day One
Details:
- Modifications to achieve blockade of checkpoints (e.g., PD1 KO) or other ligand signalling (e.g., TGFbeta dominant negative)
- ‘Armouring’ cells with membrane-bound or secreted cytokines
- Modulation of TME itself to increase tumor ‘warmth’
- Dual- and multi-targeting to prevent antigen escape
- Increasing the safety of therapies by adding ‘switches’ to turn on/off expression of required matters
