Identification of Novel pHLA Targets for Solid Tumor

Time: 10:00 am
day: Day Two


  • Advantages of intracellular targets (pHLAs) versus viral, neoantigens or conventional cell surface antigens
  • Strategies to find the most prevalent and immunogenic pHLA targets in tumors of CPI responders
  • Selection of self-antigen targets with highest tumor vs normal ratios to avoid off-tumor, on-target toxicities of TCR based therapies